Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip.
Indian J Physiol Pharmacol
;
1981 Oct-Dec; 25(4): 379-84
Artigo
em Inglês
| IMSEAR
| ID: sea-107514
ABSTRACT
MK-212 (1 x 10(-7)M -- 1 x 10(-5)M) produced dose-dependent contractions of guinea pig ileum, taenia coil and rat fundus strip. The responses to MK-212 in all three preparations were blocked competitively by cyproheptadine (1 x 10(-8)M) a 5-HT receptor antagonist. Mepyramine (1 x 10(-8)M)-H1 receptor antagonist also inhibited competitively the responses of guinea pig ileum and taenia coli to MK-212. However, it failed to block significantly the responses of rat fundus strip to MK-212. Metiamide (1 x 10(-6)M), propranolol (1 x 10(-6)M) or atropine (1 x 10(-6)M) did not produce any significant effects on MK-212 induced contractile responses of guinea pig ileum, taenia coli and rat fundus strip. Our findings suggest that MK-212 produces both 5-HT as well as histamine like effects on the guinea-pig ileum, taenia coli and rat fundus strip.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piperazinas
/
Propranolol
/
Pirazinas
/
Pirilamina
/
Ratos
/
Atropina
/
Feminino
/
Masculino
/
Receptores Histamínicos
/
Ciproeptadina
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1981
Tipo de documento:
Artigo
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