Insights into the mechanism of action of benzoyl peroxide as a tumor promoter.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 109-15
Artigo
em Inglês
| IMSEAR
| ID: sea-107598
ABSTRACT
A comparison of the mechanism of action of benzoyl peroxide, a tumor promoter was studied in three different cell lines i.e. NIH 3T3, HDCS and A431. Benzoyl peroxide was found to mediate its effect by inducing poly ADP-ribosylation in all the three cell types studied but to different extents, with histone H1 serving as a common acceptor for poly ADP-ribose. It also stimulated the activities of the antioxidant enzymes CuZn superoxide dismutase and catalase in NIH 3T3 and HDCS cells, but not in A431. Alterations in the expression of c-jun and c-fos were observed in NIH 3T3 and A431 cells. Benzoyl Peroxide appeared to mediate its effect via genetic and epigenetic mechanisms.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Poli Adenosina Difosfato Ribose
/
Superóxido Dismutase
/
Peróxido de Benzoíla
/
Proteína Quinase C
/
Células Tumorais Cultivadas
/
Carcinógenos
/
Histonas
/
Catalase
/
Regulação Neoplásica da Expressão Gênica
/
Células Cultivadas
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1997
Tipo de documento:
Artigo
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