Anti-inflammatory derivatives of indan-1-acetic acids with low gastric irritancy.
Indian J Physiol Pharmacol
;
1983 Oct-Dec; 27(4): 329-33
Artigo
em Inglês
| IMSEAR
| ID: sea-107625
ABSTRACT
In an attempt to minimize the gastric ulcerogenicity of 6-methoxyindan-1-acetic acid and 5,6-dimethoxyindan-1-acetic acid exhibiting high anti-inflammatory activity, we synthesized their esters, amides and nitrile derivatives. It was found that the anti-inflammatory activity of ethyl esters were almost equal to those of parent acids and phenylbutazone while other derivatives were less potent. Those ethyl esters were also found to be much less ulcerogenic than phenylbutazone.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Endogâmicos
/
Úlcera Gástrica
/
Relação Estrutura-Atividade
/
Masculino
/
Carragenina
/
Fenilbutazona
/
Edema
/
Indanos
/
Indenos
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1983
Tipo de documento:
Artigo
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