Effects of yohimbine on dopamine dependent behaviours in rats and mice.
Indian J Physiol Pharmacol
;
1990 Jul; 34(3): 195-200
Artigo
em Inglês
| IMSEAR
| ID: sea-107644
ABSTRACT
In the present study we have investigated the effect of yohimbine on dopamine-dependent behaviours in rats and mice. Yohimbine (1.25 to 10 mg/kg, ip) failed to block the conditioned avoidance response in rats, to inhibit the traction response in mice and to induce catalepsy in rats and mice. Pretreatment with yohimbine (1.25 to 10 mg/kg, ip) had no significant effect on apomorphine stereotypy in rats and apomorphine induced cage climbing behaviour in mice. However, pretreatment with yohimbine (1.25 to 10 mg/kg. ip) significantly increased the intensity of methamphetamine stereotypy and antagonised haloperidol catalepsy in rats. Our findings indicate that yohimbine does not possess postsynaptic striatal and mesolimbic D-2 dopamine receptor blocking activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Desempenho Psicomotor
/
Ratos
/
Comportamento Estereotipado
/
Aprendizagem da Esquiva
/
Comportamento Animal
/
Ioimbina
/
Masculino
/
Apomorfina
/
Dopamina
/
Catalepsia
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1990
Tipo de documento:
Artigo
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