Evaluation of E-721B, an indigenous herbal combination in experimental models of immediate hypersensitivity.
Indian J Physiol Pharmacol
;
2001 Jul; 45(3): 319-28
Artigo
em Inglês
| IMSEAR
| ID: sea-107656
ABSTRACT
E-721B, an indigenous herbal combination was investigated for its usefulness in immediate hypersensitivity using different animal models. The drug inhibited the mast cell degranulation induced both by antigen and compound 48/80, the Schultz-Dale response in sensitized guinea pig ileum smooth muscle preparation and the production of precipitating antibodies in 50% of tested rats. It also inhibited the mast cell degranulation in passively sensitized rats indicating its suppressive action on production of reaginic antibody (IgE). However, the drug did not inhibit the 48 hours passive cutaneous anaphylaxis reaction in rats, indicating that a single dose of the drug does not have cromoglycate like properties. All the above results indicate the inhibitory effect of E-721B on immediate hypersensitive reactions such as asthma.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Feminino
/
Masculino
/
Anafilaxia Cutânea Passiva
/
Extratos Vegetais
/
Degranulação Celular
/
Imunodifusão
/
Ratos Wistar
/
P-Metoxi-N-metilfenetilamina
/
Antialérgicos
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2001
Tipo de documento:
Artigo
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