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Effects of trichloroethylene anaesthesia on salivary paracetamol elimination.
Indian J Physiol Pharmacol ; 1993 Jan; 37(1): 79-81
Artigo em Inglês | IMSEAR | ID: sea-107671
ABSTRACT
The effect of trichloroethylene (Trielene) anaesthesia was studied in 10 young male patients undergoing short surgical procedures. Equal number of males operated upon for the same indication under epidural anaesthesia, served as a control group. Paracetamol concentrations in saliva were measured at hourly intervals on the day before and after surgery. Paracetamol half life (t1/2) significantly decreased (from 2.5 to 0.84 h) and clearance rate (CL) significantly increased (from 8.0 to 14.0 ml/min/kg) as compared to preoperative values. The control also showed significant but smaller alterations in these parameters. Our result suggests that trielene exposure may accelerate the hepatic metabolism of paracetamol.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Glândulas Salivares / Tricloroetileno / Humanos / Masculino / Adulto / Meia-Vida / Anestesia / Anestesia Geral / Acetaminofen Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1993 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Glândulas Salivares / Tricloroetileno / Humanos / Masculino / Adulto / Meia-Vida / Anestesia / Anestesia Geral / Acetaminofen Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1993 Tipo de documento: Artigo