Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 123-8
Artigo
em Inglês
| IMSEAR
| ID: sea-107690
ABSTRACT
Effects of excitatory aminoacids (EAAs) aspartate (ASP) and glutamate (GLU) in a low (50 ng, i.c.) and high dose (20 micrograms, i.c.), were studied on nociception, catalepsy and rectal temperature in albino rats. Both ASP and GLU altered the tail flick reaction time to thermal stimulation in a dose dependent manner, increasing it with low doses and reduced with high doses. Naloxone (10 micrograms, ic) antagonized the anti-nociceptive effect of EAAs while ketamine (10 micrograms, ic)-a NMDA receptor antagonist antagonized the hyperalgesic effect. These EAAs also antagonized catalepsy induced by haloperidol, chlorpromazine, trifluoperazine and morphine. Both ASP and GLU produced a hyperthermic response in all animals, including those in which hypothermia was induced by reserpine. These EAAs produced a comparable central modulatory effects on nociception, catalepsy and core temperature.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Reserpina
/
Trifluoperazina
/
Temperatura Corporal
/
Nociceptores
/
Masculino
/
Catalepsia
/
Clorpromazina
/
Ácido Aspártico
/
Ácido Glutâmico
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1997
Tipo de documento:
Artigo
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