Studies on the toxic effects of streptolysin 'O': effect on the contractility of isolated and intact mammalian and amphibian heart.
Indian J Physiol Pharmacol
;
1976 Jul-Sep; 20(3): 164-7
Artigo
em Inglês
| IMSEAR
| ID: sea-107858
ABSTRACT
The effect of streptolysin O (a streptococcal exotoxin) on the myocardial contractility of isolated and intact mammalian and amphibian heart has been investigated. Streptolysin O caused marked reduction or complete cessation of myocardial contractility of mammalian and amphibian heart both in vivo and in vitro. The effect of submaximal doses of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O was not antagonised by atropine. These observations would suggest that streptolysin O is cardiotoxic and may be involved in the causation of myocardial failure associated with acute rheumatic fever in man.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Ratos
/
Atropina
/
Estreptolisinas
/
Gatos
/
Função Atrial
/
Função Ventricular
/
Depressão Química
/
Cães
/
Cobaias
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1976
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS