Changes in ascorbic acid content and acetylcholinesterase activity in the muscle of frog following sciatectomy.
Indian J Physiol Pharmacol
;
1984 Apr-Jun; 28(2): 97-104
Artigo
em Inglês
| IMSEAR
| ID: sea-107885
ABSTRACT
Unilateral-sciatectomy for three months in the frog, Rana cyanophlictis resulted in a substantial increase on unit weight basis in the ascorbic acid (ASA) and dehydroascorbic acid (DHA) contents of the sciatectomized gastrocnemius muscle. Diketogulonic acid (DKA) levels did not vary. On whole muscle-weight basis only the ASA level increased. The AChE activity in sciatectomized muscle is significantly lower than that of the control. Partially purified preparation of the AChE from the sciatectomized muscle showed different kinetics compared to that from innervated control. In vitro additions of ASA in physiological concentration to the enzyme assay medium inhibited the AChE activity significantly and the inhibition was an un-competitive type. Reduced activity of the enzyme has been correlated to the increased concentration of ASA in the sciatectomized muscle.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Acetilcolinesterase
/
Ácido Ascórbico
/
Ranidae
/
Nervo Isquiático
/
Masculino
/
Cinética
/
Ácido Desidroascórbico
/
Ácido 2,3-Dicetogulônico
/
Animais
/
Denervação Muscular
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1984
Tipo de documento:
Artigo
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