Blockade of the dopamine depressor response by molindone, a newly introduced neuroleptic.
Indian J Physiol Pharmacol
;
1980 Apr-Jun; 24(2): 143-7
Artigo
em Inglês
| IMSEAR
| ID: sea-107970
ABSTRACT
Pretreatment with the neuroleptics, haloperidol and molindone, significantly antagonized the dopamine-induced depressor response in the anaesthetized dogs. The depressor response to dopamine was however, not significantly affected by propranolol, atropine or antazoline pretreatment. The results suggest that molindone like haloperidol, is capable of blocking the vascular dopamine receptors responsible for mediating dopamine-induced vasodilatation in the coeliac, mesenteric and renal vascular bed and fall in blood pressure.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Antipsicóticos
/
Pressão Sanguínea
/
Feminino
/
Masculino
/
Dopamina
/
Receptores Dopaminérgicos
/
Antagonistas de Dopamina
/
Cães
/
Relação Dose-Resposta a Droga
/
Haloperidol
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1980
Tipo de documento:
Artigo
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