Evaluation of the activity of receptor-operated Ca2+ channels in rat portal vein in induced hyperthyroidism.
Indian J Physiol Pharmacol
;
1999 Jul; 43(3): 389-92
Artigo
em Inglês
| IMSEAR
| ID: sea-107972
ABSTRACT
The activity of receptor-operated Ca2+ channels (ROCCs) was studied in rat portal vein in L-thyroxine-induced experimental hyperthyroidism. The following parameters were evaluated 1. NE-stimulated 45Ca influx. 2. CaCl2-induced contractile responses in Ca2+ free NE-stimulated tissues to calculate EC50 value of CaCl2. The NE (10(-6)mol) stimulated 45Ca influx and the mean EC50 value of CaCl2 did not differ significantly in portal veins isolated from hyperthyroid rats as compared to those of euthyroid control rats. The study revealed no significant change in the functional status of ROCCs in experimental hyperthyroidism.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Veia Porta
/
Ratos
/
Tiroxina
/
Masculino
/
Canais de Cálcio
/
Receptores Adrenérgicos alfa
/
Ratos Sprague-Dawley
/
Sinalização do Cálcio
/
Hipertireoidismo
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1999
Tipo de documento:
Artigo
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