Effect of protein-calorie malnutrition on drug metabolising enzymes in rat liver.
Indian J Physiol Pharmacol
;
1987 Jul-Sep; 31(3): 170-7
Artigo
em Inglês
| IMSEAR
| ID: sea-108007
ABSTRACT
Drugs are chiefly metabolised in the liver usually in two phases, viz. oxidation and conjugation. The present study was undertaken to investigate the effect of protein-calorie malnutrition (PCM), rehabilitation and effect of phenobarbitone on the hepatic drug metabolising enzymes in weanling albino rats, fed on a semisynthetic diet containing 18% or 0.5% protein. The two representative enzymes of oxidation and conjugation employed were aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase, respectively. The study revealed that PCM severely impairs oxidative drug metabolising enzyme but less so in conjugation stage. On refeeding 18% protein diet, drug metabolising enzymes returned to normal within 2-3 weeks. Phenobarbitone administration increased the activities of drug metabolising enzymes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tamanho do Órgão
/
Fenobarbital
/
Ratos
/
Ratos Endogâmicos
/
Peso Corporal
/
Masculino
/
Desnutrição Proteico-Calórica
/
Dieta
/
Glucosiltransferases
/
Aminopirina N-Desmetilase
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1987
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS