Reversal of paclitaxel induced neutropenia by Withania somnifera in mice.
Indian J Physiol Pharmacol
;
2001 Apr; 45(2): 253-7
Artigo
em Inglês
| IMSEAR
| ID: sea-108011
ABSTRACT
The effect of aqueous extract of Withania somnifera (L. Solanaceae) was studied against paclitaxel induced neutropenia in mice. After paclitaxel 1 mg/kg, i.v. administration significant fall in total WBC and absolute neutrophil count was observed on day 3 and day 5. W. Somnifera (200 mg/kg, p.o.) per se produced significant increase in neutrophil counts. W. somnifera (200 mg/kg, p.o.) when administered for 4 days before paclitaxel treatment and continued for 12 days caused significant reversal of neutropenia of paclitaxel. The findings of the study suggest the potential of W. somnifera as an adjuvant during cancer chemotherapy for the prevention of bone marrow depression associated with anticancer drugs.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plantas Medicinais
/
Masculino
/
Extratos Vegetais
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Paclitaxel
/
Índia
/
Animais
/
Fitoterapia
/
Camundongos
/
Neutropenia
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2001
Tipo de documento:
Artigo
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