Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 159-62
Artigo
em Inglês
| IMSEAR
| ID: sea-108017
ABSTRACT
Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited the Methamphetamine-induced stereotypy. The possible involvement of dopaminergic and adrenergic mechanisms and modification by Ca-channel blockers are discussed.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Comportamento Estereotipado
/
Feminino
/
Masculino
/
Bloqueadores dos Canais de Cálcio
/
Diltiazem
/
Nifedipino
/
Verapamil
/
Catalepsia
/
Depressores do Sistema Nervoso Central
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1996
Tipo de documento:
Artigo
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