Morphine hyperthermia in rats: role of neurochemical substances in brain.
Indian J Physiol Pharmacol
;
1981 Jul-Sep; 25(3): 237-45
Artigo
em Inglês
| IMSEAR
| ID: sea-108032
ABSTRACT
Central neurochemical mechanism underlying the hyperthermic effect of morphine has been investigated in rats. 200 micrograms morphine hydrochloride, when administered through cerebroventricular route at different seasonal air temperature, caused a rise in rectal temperature of rats. This hyperthermia was not affected by prior administration of antiserotonergic (pCPA, 5.6-DHT) or anticatecholaminergic (PBZ, 6-OHDA) drugs, as well as by PGE synthetase inhibitor, indomethacin. Similarity, cholinergic muscarinic or nicotinic receptor blockers, such as atropine and pentolinium/ D-tubocurarine respectively, were ineffective to modify it. Whereas, the depletion of acetylcholine in brain by pretreating the animals with hemicholinium profoundly delayed the hyperthermia, suggesting a central cholinergic involvement in morphine induced hyperthermia in rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Parassimpatolíticos
/
Antagonistas de Prostaglandina
/
Ratos
/
Antagonistas da Serotonina
/
Temperatura
/
Temperatura Corporal
/
Química Encefálica
/
Masculino
/
Catecolaminas
/
Injeções Intraventriculares
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1981
Tipo de documento:
Artigo
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