Dual action of zinc on ileal smooth muscle--zinc-calcium interaction.
Indian J Physiol Pharmacol
;
1986 Oct-Dec; 30(4): 322-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108044
ABSTRACT
Effect of zinc sulphate was studied on histamine-induced contractions on guinea-pig ileum. In doses of 1.72 X 10(-7)M or less no effects were observed. Zinc sulphate in doses of 3.44 X 10(-7)M, 6.88 X 10(-7)M and 1.72 X 10(-6)M produced dual effect. Short exposure of tissue for 10 min to zinc sulphate resulted in significant dose dependent potentiation of histamine effect whereas after washing the tissue of zinc sulphate, histamine response was inhibited significantly and in a dose dependent manner. Higher concentrations of zinc sulphate of 3.44 X 10(-6)M and above produced irreversible inhibition of histamine response. The above observations have been explained in terms of zinc-calcium interaction. It is hypothesized that interaction of zinc with calcium may take place extracellularly at membrane level and intracellularly.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Zinco
/
Feminino
/
Masculino
/
Histamina
/
Cálcio
/
Interações Medicamentosas
/
Cobaias
/
Íleo
/
Animais
/
Contração Muscular
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1986
Tipo de documento:
Artigo
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