Pharmacological screening of few new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles.
Indian J Physiol Pharmacol
;
1992 Oct; 36(4): 247-50
Artigo
em Inglês
| IMSEAR
| ID: sea-108059
ABSTRACT
Nine new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles were synthesised and confirmed on the basis of IR and nitrogen analysis. These were screened for spasmolytic, anti-inflammatory and their effects on blood pressure after determining ALD50. Compounds GK-4 i.e. 2-(diethylaminoacetyl)- amino-5-methyl-1,3,4-oxadiazole and GK-8 i.e. 2-(din-propylamino acetyl)-amino-5-ethyl-1,3,4-oxadiazole were found to be spasmolytic. Compound GK-6 i.e. 2-(diethylaminoacetyl)-amino-5-n-propyl-1,3,4-oxadiazole was found to be a potent hypotensive agent with the effect lasting for more than two hours.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxidiazóis
/
Parassimpatolíticos
/
Ratos
/
Reto
/
Relação Estrutura-Atividade
/
Pressão Sanguínea
/
Temperatura Corporal
/
Feminino
/
Masculino
/
Sistema Cardiovascular
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1992
Tipo de documento:
Artigo
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