Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture.
Indian J Physiol Pharmacol
;
1987 Oct-Dec; 31(4): 245-9
Artigo
em Inglês
| IMSEAR
| ID: sea-108084
ABSTRACT
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Artrite Reumatoide
/
Membrana Sinovial
/
Humanos
/
Divisão Celular
/
Células Cultivadas
/
Colágeno
/
Tiomalato Sódico de Ouro
/
Pró-Colágeno-Prolina Dioxigenase
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1987
Tipo de documento:
Artigo
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