Effect of medroxyprogesterone acetate on hepatic lipid profile of female rats under various states of nutrition.
Indian J Physiol Pharmacol
;
1983 Oct-Dec; 27(4): 323-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108152
ABSTRACT
The effect of medroxyprogesterone acetate (MPA) treatment on hepatic lipid profile was studied in female rats kept on protein-deficient diet, on normal restricted diet and on normal, ad libitum diet. A significant decline in total and free cholesterol levels was observed in rats kept on protein-deficient diet and on normal, restricted diet. However, protein-deficient animals exhibited a significant rise in the liver triglyceride level. In rats on normal, ad libitum diet only, MPA treatment resulted in elevated levels of triglycerides and increased esterification of cholesterol. This was mostly due to increased incorporation of acetate into esterified cholesterol and triglyceride as evident from studies using the labelled precursor. Total phospholipid content was found to be unaffected by MPA in all the groups suggesting that the drug and dietary protein level have no effect on hepatic phospholipid content.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfolipídeos
/
Ratos
/
Ratos Endogâmicos
/
Triglicerídeos
/
Feminino
/
Radioisótopos de Carbono
/
Proteínas Alimentares
/
Colesterol
/
Fígado
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1983
Tipo de documento:
Artigo
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