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Skin and liver toxicity in experimental Lantana camara poisoning in albino rats.
Indian J Physiol Pharmacol ; 1990 Jan; 34(1): 13-6
Artigo em Inglês | IMSEAR | ID: sea-108205
ABSTRACT
Dried alcoholic extract of fresh Lantana camara leaves (LE), on oral administration to albino rats of both sexes, induced photodermatitis during exposure to clear sunlight for 1 hr. Its severity was related to the dose of LE and was maximal in rats exposed to sunlight from 4 to 14 hr after feeding LE and gradually declined over 40 hr. Wavelengths of light about 540 to 570 mu only were effective. In control study, the alcoholic extract of edible spinach leaves was only 1/3 in potency and its effect lasted for less than 20 hr. LE did not raise serum bilirubin, SGOT, SGPT or cause liver injury as assessed by light microscopy. However, like CCL4 but unlike spinach extract, LE impaired excretion of BSP by liver, proportionate to the dose and also maximal at 5.5 hr declining thereafter over 40 hr.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Transtornos de Fotossensibilidade / Plantas Tóxicas / Ratos / Ratos Endogâmicos / Dermatopatias / Sulfobromoftaleína / Luz Solar / Feminino / Masculino / Extratos Vegetais Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1990 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Transtornos de Fotossensibilidade / Plantas Tóxicas / Ratos / Ratos Endogâmicos / Dermatopatias / Sulfobromoftaleína / Luz Solar / Feminino / Masculino / Extratos Vegetais Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 1990 Tipo de documento: Artigo