Protection of CCL4-induced liver damage in rats by some calcium channel blockers.
Indian J Physiol Pharmacol
;
1995 Jul; 39(3): 275-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108242
ABSTRACT
Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aspartato Aminotransferases
/
Ratos
/
Masculino
/
Intoxicação por Tetracloreto de Carbono
/
Bloqueadores dos Canais de Cálcio
/
Nimodipina
/
Nitrendipino
/
Nisoldipino
/
Ratos Wistar
/
Alanina Transaminase
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1995
Tipo de documento:
Artigo
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