Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 64-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108260
ABSTRACT
The effect of aqueous leaf extract of Azadirachta indica (A. indica) was evaluated in paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aqueous A. indica leaf extract (500 mg/kg, p.o.) significantly (P < 0.01) reduced these elevated levels of AST, ALT and gamma-GT. Paracetamol induced liver necrosis was also found to be reduced as observed macroscopically and histologically.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plantas Medicinais
/
Ratos
/
Terpenos
/
Óleos de Plantas
/
Extratos Vegetais
/
Ratos Wistar
/
Analgésicos não Narcóticos
/
Doença Hepática Induzida por Substâncias e Drogas
/
Glicerídeos
/
Fígado
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS