Effects of exogenous vitamin C on ethanol toxicity in rats.
Indian J Physiol Pharmacol
;
2000 Oct; 44(4): 401-10
Artigo
em Inglês
| IMSEAR
| ID: sea-108324
ABSTRACT
The effect of a mega dose of ascorbic acid (200 mg/100 g body wt.) on alcohol-induced toxicity in rats was evaluated. In rats administered alcohol and ascorbic acid, malondialdehyde (MDA), hydroperoxide and conjugated dienes decreased in comparison with that given alcohol alone. The reduced activities of scavenging enzymes, e.g. superoxide dismutase (SOD) and catalase, in ethanol-administered rats were also enhanced by the co-administration of ascorbic acid and ethanol. Co-administration of ethanol and ascorbic acid reduced phospholipids and MDA levels of the erythrocyte membrane in comparison with that of the ethanol fed rats. The reduction in the activities of glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamaglutamyl transpeptidase (GGT) and the decrease in triglycerides levels also clearly showed the protective action of ascorbic acid in reducing ethanol induced toxicity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfolipídeos
/
Ácido Ascórbico
/
Ratos
/
Superóxido Dismutase
/
Triglicerídeos
/
Masculino
/
Peroxidação de Lipídeos
/
Catalase
/
Depressores do Sistema Nervoso Central
/
Colesterol
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Artigo
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