Noradrenaline release by nicotinic acid.
Indian J Physiol Pharmacol
;
1975 Jul-Sep; 19(3): 129-34
Artigo
em Inglês
| IMSEAR
| ID: sea-108431
ABSTRACT
In doses (from 100 mug to 1 mg) nicotinic acid produced positive inotropic and chronotropic action on isolated frog heart. This effect was blocked by pronethalol and guanethidine administration. This effect was not observed in reserpinised frogs. Repeated administration of the same dose of nicotinic acid caused development of tachyphylaxis, in frog's heart preparation. The observations indicate that nicotinic acid induced a release of noradrenaline in frog's heart. On other preparations, such as isolated rabbit heart, rabbit's intestine and guinea pig seminal vesicles, nicotinic acid produced a nonspecific direct depressant action.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Anuros
/
Coelhos
/
Glândulas Seminais
/
Masculino
/
Norepinefrina
/
Relação Dose-Resposta a Droga
/
Cobaias
/
Coração
/
Frequência Cardíaca
/
Íleo
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1975
Tipo de documento:
Artigo
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