Efficacy of exogenous gonadotropins on the maintenance of spermatogenesis in pethidine treated albino rats.
Indian J Physiol Pharmacol
;
1998 Oct; 42(4): 509-14
Artigo
em Inglês
| IMSEAR
| ID: sea-108465
ABSTRACT
An attempt is made to induce the pethidine suppressed gonadal activities by the administration of exogenous gonadotropins (hCG, PMSG, hCG + PMSG). Administration of 5 IU gonadotropins either separately or in combination to the rats treated with pethidine for 30 days resulted in the significant increase in the weight of testis, diameter of testis and seminiferous tubules. Gonadotropin(s) treatment stimulated the spermatogenic activity which was inhibited by pethidine. Therefore the number of spermatogonia, spermatocytes, spermatids in the seminiferous tubules and spermatozoa in cauda epididymis is increased significantly. Decreased testicular cholesterol, increased protein content and weight of accessory sex organs indicate the rejuvenation of steroidogenesis. Combination of both the gonadotropins is more effective in bringing all these activities.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tamanho do Órgão
/
Ratos
/
Espermatogênese
/
Testículo
/
Masculino
/
Proteínas
/
Colesterol
/
Gonadotropinas
/
Analgésicos Opioides
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1998
Tipo de documento:
Artigo
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