Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice.
Indian J Physiol Pharmacol
;
1994 Apr; 38(2): 138-40
Artigo
em Inglês
| IMSEAR
| ID: sea-108577
ABSTRACT
The effects of pre-training and post-training administration of endosulfan on retention of a step-down passive avoidance task was studied in mice. Endosulfan at doses of 1.0 mg/kg(ip) and 2.0 mg/kg(ip) enhanced memory acquisition and retention. This effect of endosulfan was possibly mediated by interaction with cholinergic neurotransmission, as scopolamine (0.5 mg/kg, ip) significantly antagonized the memory enhancing effects of endosulfan. Clonidine (0.05 mg/kg, ip) did not have any effect on enhancement of memory produced by endosulfan, thus indicating possibly no role of noradrenergic system.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Escopolamina
/
Aprendizagem da Esquiva
/
Masculino
/
Clonidina
/
Transmissão Sináptica
/
Relação Dose-Resposta a Droga
/
Interações Medicamentosas
/
Endossulfano
/
Injeções Intraperitoneais
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1994
Tipo de documento:
Artigo
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