Some pharmacological investigations of embelin and its semisynthetic derivatives.
Indian J Physiol Pharmacol
;
1977 Jan-Mar; 21(1): 31-9
Artigo
em Inglês
| IMSEAR
| ID: sea-108585
ABSTRACT
Embelin, obtained from Embolin ribes was condensed with different primary amines. Depending on the conditions of reaction, disalts or diimines were formed. Ten such disalts and fourteen diimines were developed. Embelin and all its disalts showed analgesic activity whereas all the diimines derivatives were inactive. The disalt, 25 disobutyl amine embelin showed maximum action. Analgesic effect was noticed only after intraperitoneal administration but not after subcutaneous, intramuscular or oral administration. The compounds cause some local irritation. The possibility of peritoneal irritation rendering the animals unresponsive to experimental pain seems to deserve consideration. However, analgesic effect could be seen in dogs and cats after intravenous injection. Embelin and its disalt, 25 isobutyl amine embelin also exhibited antipyretic and antiinflammatory activities.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plantas Medicinais
/
Quinonas
/
Coelhos
/
Ratos
/
Comportamento Animal
/
Gatos
/
Galinhas
/
Cães
/
Motilidade Gastrointestinal
/
Cobaias
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1977
Tipo de documento:
Artigo
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