Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.
Indian J Physiol Pharmacol
;
1996 Oct; 40(4): 367-71
Artigo
em Inglês
| IMSEAR
| ID: sea-108697
ABSTRACT
Possible modulation of the Brewer's yeast-induced peripheral inflammation by two central neuropeptides, bradykinin and substance P (SP), was investigated in rats. Centrally administered bradykinin significantly increased pedal oedema and pain threshold whereas, SP produced significant augmentation of oedema volume and nociception. The results of the present study indicate that central bradykinin exerts pro-inflammatory and analgesic effects whereas, central SP exerts pro-inflammatory and pro-nociceptive effects on Brewer's yeast-induced peripheral inflammation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Ratos
/
Saccharomyces cerevisiae
/
Masculino
/
Bradicinina
/
Substância P
/
Ratos Sprague-Dawley
/
Edema
/
Analgésicos
/
Inflamação
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1996
Tipo de documento:
Artigo
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