Urinary bladder serosal chemoreceptor induced cardio-respiratory responses: possible pathway.
Indian J Physiol Pharmacol
;
1993 Jan; 37(1): 19-29
Artigo
em Inglês
| IMSEAR
| ID: sea-108701
ABSTRACT
There is limited experimental information about pain originating from the urinary bladder. In the present study application of 3-5 ml of 1% ammonium oxalate, 1% potassium chloride, 100m M citric acid, IM ammonium chloride, 1% oxalic acid, 0.5% sodium hydroxide, or 2 micrograms/ml bradykinin, to the serosal surface of the urinary bladder in anaesthetized dogs, resulted in an increase in heart rate, rise of both systolic and diastolic blood pressures and increase in respiratory rate and depth. These facilitatory cardio-respiratory responses were coupled with powerful contractions of the urinary bladder wall. By contrast, mucosal application of the chemicals did not bring about any significant change. The cardio-respiratory responses obtained were completely abolished on serosal application of procaine (1%), section of the hypogastric nerves or by spinalectomy at T8. Bilateral cervical vagotomy and pelvic nerve section did not modify the responses. However, the blood pressure responses were abolished by the administration of tolazoline hydrochloride, indicating a major role of sympathetics in this nociceptive reflex.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Perfusão
/
Propranolol
/
Respiração
/
Estimulação Química
/
Tolazolina
/
Vagotomia
/
Bexiga Urinária
/
Pressão Sanguínea
/
Nociceptores
/
Feminino
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1993
Tipo de documento:
Artigo
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