Synthesis and in vivo hypoglycemic screening studies on some life essential metal complexes of oral antidiabetic [N-(p-tolylsulphonyl)-N'-n butyl-urea] (tolbutamide).
Indian J Physiol Pharmacol
;
1995 Apr; 39(2): 166-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108715
ABSTRACT
Present communication deals with the synthesis of complexes of [N-(p-tolylsulphonyl)-N'-n butyl-urea], with certain transition metals viz. Cu(II), Zn(II), Fe(II) and Cd(II). Structures of all the complexes have been established on the basis of their consistent elemental and spectral analysis. Also, it reports their in vivo hypoglycemic screening on albino rats. Out of all the complexes studied, Zn-Tolbutamide complex could be recommended as more potent hypoglycemic agent in lieu of tolbutamide alone.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Espectrofotometria Infravermelho
/
Tolbutamida
/
Zinco
/
Cádmio
/
Administração Oral
/
Cobre
/
Sinergismo Farmacológico
/
Hipoglicemia
/
Ferro
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1995
Tipo de documento:
Artigo
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