Effect of nimodipine on male reproductive functions in rats.
Indian J Physiol Pharmacol
;
2000 Oct; 44(4): 449-55
Artigo
em Inglês
| IMSEAR
| ID: sea-108734
ABSTRACT
Nimodipine, a dihydropyridine calcium channel blocker, was administered orally using two different doses (40 mg and 60 mg/kg/day) to rats. Both short term (2 weeks) and long term (6 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and acrozomal reaction. Zona-pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Nimodipine stimulated Ca2+ ATPase activity in isolated plasma membrane of rate spermatozoa. In conclusion, short term and long term administration of nimodipine has deleterious effect on male reproductive functions in rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Reprodução
/
Contagem de Espermatozoides
/
Motilidade dos Espermatozoides
/
Zona Pelúcida
/
Feminino
/
Masculino
/
Bloqueadores dos Canais de Cálcio
/
Nimodipina
/
ATPases Transportadoras de Cálcio
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS