Interaction of pargyline with tolbutamide in rabbits.
Indian J Physiol Pharmacol
;
1995 Jan; 39(1): 71-3
Artigo
em Inglês
| IMSEAR
| ID: sea-108795
ABSTRACT
Acute treatment of rabbits with pargyline (50 mg/kg, ip, 30 min before tolbutamide) significantly increased the elimination half life and AUC0-->infinity of tolbutamide resulting in prolonged hypoglycaemia. Similar treatment also prolonged the half life of antipyrine which is used as model drug to indicate hepatic microsomal enzyme activity in vivo confirming that pargyline treatment delayed the elimination of tolbutamide in rabbits by inhibiting its hepatic metabolism.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pargilina
/
Coelhos
/
Tolbutamida
/
Glicemia
/
Feminino
/
Masculino
/
Microssomos Hepáticos
/
Antipirina
/
Interações Medicamentosas
/
Meia-Vida
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1995
Tipo de documento:
Artigo
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