Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat.
Indian J Physiol Pharmacol
;
1983 Jul-Sep; 27(3): 241-4
Artigo
em Inglês
| IMSEAR
| ID: sea-108832
ABSTRACT
Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Antipsicóticos
/
Humanos
/
Masculino
/
Dopamina
/
Catalepsia
/
Clorpromazina
/
Alfa-Metiltirosina
/
Sinergismo Farmacológico
/
Haloperidol
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1983
Tipo de documento:
Artigo
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