Effects of topically applied sulphur mustard on tissue glycogen, blood glucose, lactate and pyruvate in mice.
Indian J Physiol Pharmacol
;
1992 Jul; 36(3): 219-21
Artigo
em Inglês
| IMSEAR
| ID: sea-108874
ABSTRACT
Bis-2-Chloroethyl sulphide, commonly known as sulphur mustard (SM) or mustard gas, an alkylating agent, is frequently used as a chemical warfare agent. Inhibition of glycolysis has been related to skin injury and cell death. The effects of SM on tissue glycogen, blood glucose, lactate/pyruvate ratio were investigated in the present study. After a single dermal application of 1.0 LD50 SM in mice, a significant hyperglycemia was observed at 24 hr post exposure. There was a corresponding decrease in liver glycogen content, with no alteration in glycogen content of brain, muscles and kidney. Blood pyruvate and lactate levels were not appreciably altered.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piruvatos
/
Glicemia
/
Química Encefálica
/
Masculino
/
Administração Tópica
/
Ácido Láctico
/
Ácido Pirúvico
/
Glicogênio
/
Lactatos
/
Fígado
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1992
Tipo de documento:
Artigo
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