Changes in brain acetylcholine of rats after dermal application of fenitrothion (Sumithion).
Indian J Physiol Pharmacol
;
1977 Apr-Jun; 21(2): 124-4
Artigo
em Inglês
| IMSEAR
| ID: sea-108919
ABSTRACT
Fenitrothion (Sumithion), and organophosphorous insectide, was applied dermally to rats. Cholinesterase activity was measured in blood and brain. The concentration of the pesticide in blood plasma and acetylcholine in brain were estimated at different intervals. The maximum concentration of Fenitrothion in the plasma was found at 4 hrs while significantly elevated levels of acetylcholine were present in the brain till 24 hrs. The results suggest that the compound was readily absorbed by dermal route to produce inhibition of cholinesterase and a consequent persistent increase in brain acetylcholine.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Acetilcolinesterase
/
Ratos
/
Fatores de Tempo
/
Encéfalo
/
Química Encefálica
/
Feminino
/
Acetilcolina
/
Administração Tópica
/
Fenitrotion
/
Animais
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1977
Tipo de documento:
Artigo
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