Role of emotionality on inter and intrastrain variations in imipramine response. a comparative study in Balb/c and Swiss mice.
Indian J Physiol Pharmacol
;
2005 Oct-Dec; 49(4): 449-54
Artigo
em Inglês
| IMSEAR
| ID: sea-108920
ABSTRACT
Association between emotionality and effect of imipramine on immobility time in forced swimming test was investigated in Swiss and Balb/c mice. Mice of both the strains were segregated into normal emotional (mean +/- 1SD), low emotional (> mean + 1SD) and high emotional (< mean - 1SD) based on their performance with respect to each indices of emotionality in novel arena and elevated plus maze. Baseline immobility and effect of imipramine (20 mg/kg, po) on immobility time was evaluated in these emotionally different groups of mice using forced swimming test model. Baseline immobility time of low emotional mice was found to be significantly less (P<0.01) and that of high emotional mice was found to be significantly more (P<0.01) when compared to normal emotional mice of both the strains. Immobility time after imipramine administration was found to be significantly less (P<0.05) with low emotional mice and significantly more (P<0.01) with high emotional mice when compared to normal emotional mice of both the strains.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ansiedade
/
Especificidade da Espécie
/
Defecação
/
Emoções
/
Meio Ambiente
/
Imipramina
/
Animais
/
Camundongos
/
Camundongos Endogâmicos BALB C
/
Atividade Motora
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2005
Tipo de documento:
Artigo
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