Increased glycated hemoglobin level in non-diabetic nephrotic children is associated with oxidative stress.
Indian J Physiol Pharmacol
;
2007 Apr-Jun; 51(2): 153-9
Artigo
em Inglês
| IMSEAR
| ID: sea-108931
ABSTRACT
Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of nephrotic syndrome. Possible interrelations of glycated hemoglobin with reduced glutathione and malondialdehyde were evaluated in nephrotic syndrome patients. Eighteen nephrotic syndrome patients and 15 healthy controls were enrolled for this study. Glycated hemoglobin, reduced glutathione, malondialdehyde and fasting glucose were analyzed for their correlation in both the groups. In nephrotic syndrome patients, while glycated hemoglobin and malondialdehyde levels were found to be significantly increased, glutathione levels decreased significantly when compared with controls. Glycated hemoglobin was found to have a significant positive correlation with malondialdehyde and a negative correlation with glutathione. Erythrocytes depleted of glutathione, by pre-treatment with 1-chloro-2, 4-dinitrobenezene, were found to have higher glycated hemoglobin levels when compared with erythrocytes incubated with glucose alone. These data suggest that glycated hemoglobin levels are closely associated with malondialdehyde and glutathione in nephrotic syndrome patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Hemoglobinas Glicadas
/
Modelos Lineares
/
Criança
/
Pré-Escolar
/
Adolescente
/
Estresse Oxidativo
/
Glutationa
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2007
Tipo de documento:
Artigo
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