Anti-implantation effect of a bone-marrow cytokine-BIM.
Indian J Physiol Pharmacol
;
1998 Jul; 42(3): 352-8
Artigo
em Inglês
| IMSEAR
| ID: sea-108967
ABSTRACT
Successful implantation of blastocyst is dependent upon a cytokine induced localized immunosuppression at uterus. BIM, a bone marrow secreted bio-immunomodulator (BIM) has been observed to have positive immunomodulatory activity in immunosuppressed cases. As pregnancy is associated with immunosuppression upregulation of the suppressed immune system by injection of BIM (conc. 0.08 microg/g b.wt once in rats b.wt. <150 gm or 0.2 microg/g b.wt thrice in rats weighing > 160 gm) is believed to prevent implantation. The anti-implantation action of BIM is probably mediated via mononuclear cells at site of uterus, the effect is reversible and a single dose did not affect the estrous cycle. Multiple dose of BIM however, produce prolonged diestrous and this is probably an autonomic phenomena.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Implantação do Embrião
/
Ratos
/
Compostos Azo
/
Azul Tripano
/
Útero
/
Líquidos Corporais
/
Medula Óssea
/
Feminino
/
Masculino
/
Gravidez
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1998
Tipo de documento:
Artigo
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