Role of 5-HT on increased permeability of blood-brain barrier under heat stress.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 259-67
Artigo
em Inglês
| IMSEAR
| ID: sea-108971
ABSTRACT
Exposure of young rats (9-10 wks) to chronic summer heat (36 degrees C) or acute heat (38 degrees C 4hr) increased the BBB permeability to Evans blue albumin complex (MW 68,000) and 131I-sodium (MW 154) in different brain regions which correlated well with the increased level of 5-HT in plasma and brain. This increased permeability of BBB and the increased 5-HT level were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment however, prevented only the increased permeability of BBB, the plasma and brain 5-HT level continued to remain high. These results indicate a probable role of 5-HT as one of the factors leading to the increased permeability of BBB in young rats following heat stress.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Permeabilidade
/
Ratos
/
Vimblastina
/
Química Encefálica
/
Feminino
/
Masculino
/
Barreira Hematoencefálica
/
Serotonina
/
Indometacina
/
Fenclonina
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1984
Tipo de documento:
Artigo
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