Effect of country liquor (Indian alcoholic beverage) on carcinogen activating and detoxifying enzymes.
Indian J Physiol Pharmacol
;
1993 Jan; 37(1): 85-7
Artigo
em Inglês
| IMSEAR
| ID: sea-108984
ABSTRACT
The levels of some important drug activating and detoxyfying enzymes were estimated in the livers of Swiss mice treated with a local brand of country liquor. Following liquor ingestion in male mice elevated levels of hepatic cytochrome P-450 were observed, while female mice did not show this. Cytochrome b5 levels remained unchanged. Similarly in male mice, increase in hepatic reduced glutathione levels were obtained while in female mice, decrease in this was observed. The activity of glutathione S-transferase was not changed. It is suggested that the increases in cytochrome P-450 and in hepatic reduced glutathione may be important determinants in carcinogenecity of the country liquors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Masculino
/
Microssomos Hepáticos
/
Citocromos b5
/
Fatores Sexuais
/
Sistema Enzimático do Citocromo P-450
/
Bebidas Alcoólicas
/
Glutationa
/
Glutationa Transferase
/
Índia
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1993
Tipo de documento:
Artigo
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