Evaluation of a new premedication protocol for administration of equine rabies immunoglobulin in patients with hypersensitivity.
Indian J Public Health
;
2007 Apr-Jun; 51(2): 91-6
Artigo
em Inglês
| IMSEAR
| ID: sea-109145
ABSTRACT
OBJECTIVES:
The present study was undertaken to standardize skin testing and to develop a safe and effective premedication protocol for administration of ERIG in those with skin test positivity/hypersensitivity.METHODS:
A method of grading of skin testing was developed using injection histamine as a positive control. This was evaluated by using it on 517 subjects who had severe (WHO category III) exposure to rabies. A premedication protocol consisting of injections pheniramine, ranitidine, hydrocortisone and adrenaline was evaluated by using it on fifty one subjects who were skin test positive/hypersensitive to ERIG.RESULTS:
The premedication protocol was safe and effective as all the S1 subjects could be administered the full dose of ERIG despite being skin test positive/hypersensitive to ERIG. Besides the premedication drugs/protocol did not affect the immune response to vaccine and ERIG therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pré-Medicação
/
Raiva
/
Ranitidina
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Imunoglobulinas
/
Recém-Nascido
/
Testes Intradérmicos
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Indian J Public Health
Ano de publicação:
2007
Tipo de documento:
Artigo
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