Prevalence and some epidemiological factors of beta thalassaemia trait in Sindhi community of Nagpur City, India.
Indian J Public Health
;
2008 Jan-Mar; 52(1): 11-5
Artigo
em Inglês
| IMSEAR
| ID: sea-110297
ABSTRACT
OBJECTIVE:
To study the prevalence of Beta thalassaemia trait (bTT) in Sindhi community of Nagpur City and to study association between bTT and some epidemiological factors like age at menarche in females, past history of diagnosis and treatment of anaemia and the current haemoglobin concentration.METHODS:
The present cross-sectional study was undertaken among 446, young, apparently healthy, unrelated (by blood) Sindhi individuals before marriage or before reproduction. Blood samples were processed for Beta thalassaemia trait (bTT) using two stage approaches. Two screening tests namely Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) and RBC indices including Mean Corpuscular Volume (MCV) were performed on all samples and those positive for either one or both screening tests were further investigated for HbA2 level estimation by Haemoglobin electrophoresis on Cellulose acetate paper. HbA2 level of > 4.5% was taken as confirmatory of bTT.RESULTS:
The prevalence of bTT in Sindhis of Nagpur was found to be 16.81%. No significant association was found between bTT & a delayed age at menarche, however a significantly higher number of trait carrier females had past history of diagnosis and treatment of anaemia while a significantly higher number of both male and female trait carriers had current haemoglobin concentration in anaemic range.CONCLUSION:
The present study confirmed high prevalence of bTT in Sindhis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Exames Pré-Nupciais
/
Diagnóstico Pré-Natal
/
Feminino
/
Humanos
/
Masculino
/
Prevalência
/
Estudos Transversais
/
Talassemia beta
/
Heterozigoto
/
Índia
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Public Health
Ano de publicação:
2008
Tipo de documento:
Artigo
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