Cytokeratin expression in human fetal tongue and buccal mucosa.
J Biosci
;
2000 Sep; 25(3): 235-42
Artigo
em Inglês
| IMSEAR
| ID: sea-110798
ABSTRACT
Expression of cytokeratins (CK), a subset of intermediate filament (IF) proteins in epithelia, is developmentally regulated. CK expression may also change after malignant transformation. Our earlier studies on CK expression in human oral tumours and pre-cancerous lesions have shown specific changes in CK expression. We analysed CK expression in human tongue and buccal mucosa (BM) in fetuses in the embryonic age group of 16 to 27 weeks using biochemical and immunohistochemical techniques to find out whether there is any similarity in CK expression in human oral squamous cell carcinomas (SCC) and fetal oral tissues. CK 1, 8 and 18 were detected in a majority of samples using both techniques. Our earlier studies had shown aberrant expression of CK 1 and 18 in many of the oral SCC and leukoplakias. Studies by immunohistochemistry showed that these different CK antigens were expressed in different cell layers. CK 1(2) were present in the stratified epithelial layers whereas CK 8 and 18 were restricted to glandular epithelium. Till 27 weeks of gestation, both tongue and BM expressed CK 1, 8 and 18 along with CK 6 and 16. Thus, fetal tissues showed some similarities in CK pattern with their respective SCC.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Eletroforese em Gel Bidimensional
/
Idade Gestacional
/
Regulação da Expressão Gênica no Desenvolvimento
/
Técnica Indireta de Fluorescência para Anticorpo
/
Isoformas de Proteínas
/
Proteínas Fetais
/
Queratinas
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
2000
Tipo de documento:
Artigo
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