Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites.
J Biosci
;
2007 Aug; 32(5): 999-1004
Artigo
em Inglês
| IMSEAR
| ID: sea-111147
ABSTRACT
Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor.Occurrence of proline was very high for calpain 10 gene and glucose transporter.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Filogenia
/
Sítios de Ligação
/
Humanos
/
Proteínas
/
Valor Preditivo dos Testes
/
Homologia de Sequência de Aminoácidos
/
Sequência Conservada
/
Domínio Catalítico
/
Análise de Sequência de Proteína
/
Motivos de Aminoácidos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
2007
Tipo de documento:
Artigo
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