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Thermosensors in eubacteria: role and evolution.
J Biosci ; 2007 Apr; 32(3): 549-57
Artigo em Inglês | IMSEAR | ID: sea-111209
ABSTRACT
Temperature is an important physical stress factor sensed by bacteria and used to regulate gene expression. Three different macromolecules have been identified being able to sense temperature DNA, mRNA and proteins. Depending on the induction mechanism, two different pathways have to be distinguished, namely the heat shock response and the high temperature response. While the heat shock response is induced by temperature increments and is transient, the high temperature response needs a specific temperature to become induced and proceeds as long as cells are exposed to that temperature. The heat shock response is induced by denatured proteins and aimed to prevent formation of protein aggregates by refolding or degradation, and the high temperature response is mainly used by pathogenic bacteria to detect entry into a mammalian host followed by induction of their virulence genes. All known high temperature sensors are present in two alternative conformations depending on the temperature. Heat shock sensors are either molecular chaperones or proteases which keep either a positive transcriptional regulator inactive or a negative regulator active or do not attack the regulator, respectively, under physiological conditions. Denatured proteins either titrate the molecular chaperones or activate the protease. The evolution of the different temperature sensors is discussed.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Bactérias / Regulação da Temperatura Corporal / Adaptação Fisiológica / Evolução Biológica / Temperatura Alta Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: J Biosci Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Bactérias / Regulação da Temperatura Corporal / Adaptação Fisiológica / Evolução Biológica / Temperatura Alta Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: J Biosci Ano de publicação: 2007 Tipo de documento: Artigo