Mechanism of store-operated calcium entry.
J Biosci
;
2000 Dec; 25(4): 397-404
Artigo
em Inglês
| IMSEAR
| ID: sea-111297
ABSTRACT
Activation of receptors coupled to the phospholipase C/IP3 signalling pathway results in a rapid release of calcium from its intracellular stores, eventually leading to depletion of these stores. Calcium store depletion triggers an influx of extracellular calcium across the plasma membrane, a mechanism known as the store-operated calcium entry or capacitative calcium entry. Capacitative calcium current plays a key role in replenishing calcium stores and activating various physiological processes. Despite considerable efforts, very little is known about the molecular nature of the capacitative channel and the signalling pathway that activates it. This review summarizes our current knowledge about store operated calcium entry and suggests possible hypotheses for its mode of activation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Canais de Cálcio
/
Transdução de Sinais
/
Membrana Celular
/
Cálcio
/
Citosol
/
Fosfatidilinositol 3-Quinase
/
Animais
/
Modelos Biológicos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
J Biosci
Ano de publicação:
2000
Tipo de documento:
Artigo
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