A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer.
J Cancer Res Ther
;
2006 Jul-Sep; 2(3): 132-5
Artigo
em Inglês
| IMSEAR
| ID: sea-111403
ABSTRACT
PURPOSE:
To evaluate the feasibility and results of sildenafil used as radiosensitizer by causing penile vasodilatation and reducing tumor hypoxia in radical radiotherapy for penile cancer. MATERIALS ANDMETHODS:
Three men with histopathologic diagnosis of squamous carcinoma of penis were treated with radical external radiotherapy with concomitant sildenafil. Acute and late adverse events were noted according to RTOG toxicity criteria. Response to radiotherapy, as well as disease-free and overall survivals, was evaluated.RESULTS:
All three patients achieved tumescence, completed the treatment and achieved complete response. One patient had recurrence at 10 months and died of the disease after 23 months from starting the treatment. Other two patients are disease-free and alive at 48 and 53 months respectively. No excess acute or late adverse event was observed.CONCLUSION:
Sildenafil may act as radiosensitizer by causing penile vasodilatation and reducing hypoxia. Larger controlled studies are required to validate the hypothesis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Penianas
/
Inibidores de Fosfodiesterase
/
Piperazinas
/
Purinas
/
Sulfonas
/
Idoso de 80 Anos ou mais
/
Humanos
/
Masculino
/
Carcinoma
/
Hipóxia Celular
Limite:
Aged80
Idioma:
Inglês
Revista:
J Cancer Res Ther
Assunto da revista:
Neoplasms
/
Therapeutics
Ano de publicação:
2006
Tipo de documento:
Artigo
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