Conventional and fluorescence in situ hybridization analysis of three-way complex BCR-ABL rearrangement in a chronic myeloid leukemia patient.
J Cancer Res Ther
;
2007 Apr-Jun; 3(2): 124-6
Artigo
em Inglês
| IMSEAR
| ID: sea-111460
ABSTRACT
Chromosomal analysis was carried out in bone marrow sample of an 11-year-old girl suspected of myeloproliferative disorder. Conventional G-banding study detected a complex three-way translocation involving 7, 9 and 22, which has resulted in the formation of a variant Philadelphia chromosome causing rearrangement of abl and bcr genes in 87% cells. Fluorescence in situ hybridization (FISH) confirmed the fusion of bcr-abl oncogene. Thus the bone marrow karyotype was observed as 46,XX (13%)/46,XX,t(7;9;22)(q11;q34;q11) (87%). Hyperdiploidy was present in two cells. In this study, both conventional cytogenetic and FISH diagnosis proved to be significant to identify the variant nature of the Philadelphia chromosome and hyperdiploid condition for introduction of a suitable treatment regimen and estimation of life expectancy of the young girl.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Translocação Genética
/
Medula Óssea
/
Cromossomos Humanos Par 7
/
Cromossomo Filadélfia
/
Feminino
/
Humanos
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Criança
/
Proteínas de Fusão bcr-abl
/
Hibridização in Situ Fluorescente
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
J Cancer Res Ther
Assunto da revista:
Neoplasms
/
Therapeutics
Ano de publicação:
2007
Tipo de documento:
Artigo
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