Brain tumor and role of beta-carotene, a-tocopherol, superoxide dismutase and glutathione peroxidase.
J Cancer Res Ther
;
2006 Jan-Mar; 2(1): 24-7
Artigo
em Inglês
| IMSEAR
| ID: sea-111570
ABSTRACT
The erythrocyte levels of the antioxidant enzymes SOD and GPx, and serum levels of antioxidants vitamins beta-carotene and beta-tocopherol were estimated in various types of brain tumors, and were compared with the levels in controls. Statistically significant (P<.001) diminished levels of beta-carotene, beta-tocopherol, SOD and GPx, were observed in all the brain tumor patients as compared to controls. Malignant tumor also showed a relative decrease in antioxidant levels as compared to benign tumors. Comparison of histopathological sections of brain tumors also suggested a inverse relationship between antioxidant level and grades of malignancy. Marked decrease in antioxidant levels may have a role in genesis of considerable oxidative stress in brain tumors. Furthermore, the degree of decline in antioxidant levels may indicate severity of malignancy in brain tumors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Superóxido Dismutase
/
Química Encefálica
/
Neoplasias Encefálicas
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Adolescente
/
Estresse Oxidativo
Idioma:
Inglês
Revista:
J Cancer Res Ther
Assunto da revista:
Neoplasms
/
Therapeutics
Ano de publicação:
2006
Tipo de documento:
Artigo
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