Usefulness of ELISA using antigen A60 in serodiagnosis of neurotuberculosis.
Artigo
em Inglês
| IMSEAR
| ID: sea-111729
ABSTRACT
Anti-mycobacterial antibody to A60 antigen were quantified in the sera and cerebrospinal fluid (csf) samples of one hundred patients of neurotuberculosis and twenty non-tubercular controls by immunoenzymatic (ELISA) assay. Sixty three patients (63%) had "significant" antibody titres in serum and/or CSF samples. In contrast, none of the samples from the control group showed this level of antibody concentration. The evaluation of this assay in tuberculoma (group A, 79 cases) vis-a-vis tubercular meningitis or TBM (group B, 21 patients) revealed significant antibody levels in the former 46 (58.2%) in comparison to 17 (77.3%) in the latter group. A positive relationship was observed in the titres of anti-mycobacterial antibodies in serum and in CSF both in cases of tuberculoma and TBM. This study indicates the utility of A60 antigen ELISA assay in categorising these patients into tubercular aetiology specially in the absence of bacteriological isolation from CSF which still remains the gold standard diagnostic criterion.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tuberculoma
/
Tuberculose Meníngea
/
Humanos
/
Ensaio de Imunoadsorção Enzimática
/
Testes Sorológicos
/
Glicoproteínas de Membrana
/
Doenças do Sistema Nervoso Central
/
Diagnóstico Diferencial
/
Anticorpos Antibacterianos
/
Mycobacterium
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Ano de publicação:
1996
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS